SHORT COMMUNICATION Chronic ethanol consumption does not affect action of propofol on rat hippocampal acetylcholine release in vivo
نویسندگان
چکیده
Results. Propofol 50 mg kg 1 i.p. significantly decreased basal hippocampal ACh release in ethanol-treated and control rats by 50.4 (SEM 4.7)% and 38.3 (11.1)%, respectively. Propofol 100 mg kg 1 i.p. significantly decreased basal hippocampal ACh release in ethanol-treated and control rats by 67.5 (3.7)% and 55.9 (7.4)%, respectively. The reduction in hippocampal ACh release induced by 50 or 100 mg kg 1 i.p. propofol was not significantly different between ethanoltreated and control rats. There was no significant difference in the duration of sleep between the two groups.
منابع مشابه
Chronic ethanol consumption does not affect action of propofol on rat hippocampal acetylcholine release in vivo.
BACKGROUND The aim of this study was to examine ethanol-consumption-related changes in the effects of propofol on rat hippocampal acetylcholine (ACh) release. METHODS Male Sprague-Dawley rats received a solution of ethanol (20% v/v) for 24 weeks while controls received tap water. The effects of propofol were examined by in vivo microdialysis, with ACh release from the hippocampal regions dete...
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